Citalopram (Celexa)

10

20

40

0

1+

1+

3+

Watch for QTc prolongation if >40 mg daily

Escitalopram (Cipralex)

5

10

20 (30*)

0

1+

1+

3+

S-isomner of Citalopram

Fluoxetine (Prozac)

10

20

80

0

1+

1+

3+

Long half-life useful for teenagers; however, caution in elderly
Watch for drug-drug interactions

Sertraline (Zoloft)

25

50

200

1+

0-1+

1+

3+

May be used in panic disorder; consider in postpartum

Paroxetine (Paxil)

10

20

50

1+

0-1+

2+

4+

Short half-life; watch for discontinuation syndrome
Avoid in elderly and pregnancy

Vortioxetine (Trintellix)

5

10

20

0

0

0

0-3+

Sexual side effects are dose dependent
Crossover when switching

Fluvoxamine (Luvox)

50

100

300

1+

0-1+

1+

3+

Significant GI side effects

Venlafaxine XR (Effexor)

37.5

75

225 (300*)

1+

1+

0

3+

May increase blood pressure! Watch for discontinuation syndrome

Desvenlafaxine (Pristiq)

50

50

100

1+

0

0

3+

May increase blood pressure! Watch for discontinuation syndrome

Duloxetine (Cymbalta)

30

60 

120

0

0

0

3+

Also approved for several pain conditions

Bupropion XL (Welbutrin)

150

300

300 (450*)

0

1+

0

0

Avoid in those prone to seizures and in eating disorder

Mirtazapine (Remeron)

30

30

45

4+

1+

4+

1+

Significant sedation and increased appetite.